Physiogically based pharmacokinetic (PBPK)
Physiologically based pharmacokinetic (PBPK) models are stock and flow models used to think about how chemicals move and concentrate within the body. While many dose-response experiments look only at the dose applied to the animal (food, air or skin), understanding what goes on inside the body can provide much better information on why a given response occurs.
PBPK is also a type of pharmacokinetics where physiology and anatomy of the animal or human body, and the biochemistry of the chemicals of interest, are incorporated into a model for simulation by software. PBPK is a powerful tool for many types of extrapolation, including species to species, route to route and dose to dose. It is also a mathematical modelling technique for prediction of the absorption, distribution, metabolization and excretion (AMDE) of a compound in humans and other species used in pharmaceutical research.
Basic PBPK Models
A Physiologically Based PharmacoKinetic (PBPK) model for humans descibes the body as a set of interconnected compartments, or continuous stirred tank reactors (CSTRs). Each compartment can describe either an organ or a tissue.
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June 13th, 2007 15:25
[…] Bio Transfer Factor (BTF) is a constant to describe the relationship between chemical substance in a tissue and the rate of ingestion to body of particular toxic agent (chemical substance). Often, the concentration forms a linear or straight line as the rate of chemical ingestion inreases as well. Thus at this case, the BTF is constant. I will make this simpler, BTF is a ratio between the amount of chemical per amount of body weight (mg A/kgtissue) and the rate of ingestion of chemical entering the body (mg A/day. If you do not follow previous post, you are probably unfamiliar with A, A is representing toxic chemicals. I suggest you read the example about physiologically based pharmacokinetics, part 1, part 2 and part 3, especially this example is related to those examples as well. […]