Online seminar on PK/PD/PBPK Modeling using acslXtreme
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AEgis Technologies would like to invite you to attend an online seminar on PK/PD/PBPK Modeling using acslXtreme®.
This online seminar demonstrates the implementation and analysis of pharmacokinetic, pharmacodynamic and physiologically-based pharmacokinetic models using the acslXtreme modeling and simulation environment.
By developing and analyzing a few example models, we will introduce you to the acslXtreme environment and show you how acslXtreme can be used in applications ranging from prediction of drug dispersion and therapeutic thresholds, to determination of exposure limits for toxicological risk assessment.
Topics discussed during the seminar will include:
- Import and exploration of clinical/laboratory data in the acslXtreme environment
- Specification of PK models using both the CSL language and the PK toolkit for graphical modeling
- Estimation of PK parameters using maximum likelihood parameter estimation in acslXtreme
- Linking a PD model to an acslXtreme kinetic model
- Prediction of the effects of various dosing regimens using the acslXtreme analysis language (”M language”)
- Using an acslXtreme PBPK model to predict internal dose metrics from toxic exposure
- Animal to human extrapolation using an acslXtreme PBPK model
- Determination of external exposure limits based on internal dose metrics
- Uncertainty analysis of acslXtreme model predictions using Monte Carlo techniques
On-line Seminars will take place:
Thursday, August 9th, 2007 1:00 PM (CDT) - Full
Tuesday, August 14th, 2007 9:00 AM (CDT)
Tuesday, August 14th, 2007 2:00 PM (CDT)
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